Serious Global IQ Scores

[Kaz]

For those who don't know, even a one-point difference is huge.

 

[Haruhi Suzumiya]

nuke bellow 95

 

[chudur-budur]

nuke bellow 95

Nuke below 101.

 

[FeminismIsCancer]

65 is literally gorilla tier.

 

[01zephyr10]

England owes me 100 IQ Points.

 

[liazi]

cba to look into it but it sounds dubious af

 

[Incellectual_Anon]

Sample:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	65622	C=0.61295	T=0.38705
European	Sub	46144	C=0.67573	T=0.32427
African	Sub	5836	C=0.4231	T=0.5769
African Others	Sub	202	C=0.371	T=0.629
African American	Sub	5634	C=0.4249	T=0.5751
Asian	Sub	502	C=0.189	T=0.811
East Asian	Sub	402	C=0.169	T=0.831

 

[Incellectual_Anon]

An international team of scientists has successfully mapped the human genes that either increase or disrupt the brain's resistance to various neurological and mental illnesses. This study, presented in the journal Nature Genetics, has identified novel genes that could provide insight into the differences that exist in brain size and intelligence. The results could also lead to the development of new drug treatments.

'Our individual centres couldn't review enough brain scans to obtain definitive results,' says Professor Thompson. 'By sharing our data with project ENIGMA, we created a sample large enough to reveal clear patterns in genetic variation and show how these changes physically alter the brain.'

The researchers observed subtle shifts in the genetic code of subjects whose images showed smaller brains. The memory centres were also smaller, according to the team. It should be noted that no matter where the subjects hailed from, the same genes affected the brain in similar ways.

The team also found genes that explain individual differences in intelligence, uncovering a variant in a gene called HMGA2 that affected both brain size and intelligence. DNA has four bases: A, C, T and G; subjects whose HMGA2 gene had C instead of T had larger brains and recorded higher results on standardised intelligence quotient (IQ) tests.

Connection found between genes and brain size, intelligence

An international team of scientists has successfully mapped the human genes that either increase or disrupt the brain's resistance to...

cordis.europa.eu

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	249570	C=0.462279	T=0.537721
European	Sub	218988	C=0.472976	T=0.527024
African	Sub	7884	C=0.5008	T=0.4992
African Others	Sub	290	C=0.510	T=0.490
African American	Sub	7594	C=0.5004	T=0.4996

 

[Incellectual_Anon]

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer’s disease1,2 and is reduced in schizophrenia3, major depression4 and mesial temporal lobe epilepsy5. Whereas many brain imaging phenotypes are highly heritable6,7, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10−16) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10−12). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10−7).

Identification of common variants associated with human hippocampal and intracranial volumes

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer’s disease[,] and is reduced ...

www.ncbi.nlm.nih.gov

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	279594	T=0.887716	C=0.112284
European	Sub	244240	T=0.898444	C=0.101556
African	Sub	8612	T=0.6227	C=0.3773
African Others	Sub	304	T=0.516	C=0.484
African American	Sub	8308	T=0.6266	C=0.3734

rs7294919 was not associated with full-scale IQ (P = 0.139) or PIQ (P = 0.489) but showed nominal association with VIQ (effect allele: C; β = 0.126, S.E. = 0.062; P = 0.043).

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	279594	T=0.887716	C=0.112284
European	Sub	244240	T=0.898444	C=0.101556
African	Sub	8612	T=0.6227	C=0.3773
African Others	Sub	304	T=0.516	C=0.484
African American	Sub	8308	T=0.6266	C=0.3734

 

[Incellectual_Anon]

We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10−7).

rs10494373 is at 1q23.3: position 160,885,986. Effect allele, C; non-effect allele, A.

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	197560	A=0.923679	C=0.076321
European	Sub	174448	A=0.922739	C=0.077261
African	Sub	7092	A=0.9267	C=0.0733
African Others	Sub	264	A=0.951	C=0.049
African American	Sub	6828	A=0.9257	C=0.0743

 

[Incellectual_Anon]

rs17070145 RefSNP Report - dbSNP - NCBI

www.ncbi.nlm.nih.gov

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	65622	C=0.61295	T=0.38705
European	Sub	46144	C=0.67573	T=0.32427
African	Sub	5836	C=0.4231	T=0.5769
African Others	Sub	202	C=0.371	T=0.629
African American	Sub	5634	C=0.4249	T=0.5751
Asian	Sub	502	C=0.189	T=0.811
East Asian	Sub	402	C=0.169	T=0.831

 

[Incellectual_Anon]

Git Dat Money G

rs79600142 RefSNP Report - dbSNP - NCBI

www.ncbi.nlm.nih.gov

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	34932	T=0.81246	C=0.18754, G=0.00000
European	Sub	30102	T=0.79496	C=0.20504, G=0.00000
African	Sub	2902	T=0.9628	C=0.0372, G=0.0000
African Others	Sub	114	T=0.991	C=0.009, G=0.000
African American	Sub	2788	T=0.9616	C=0.0384, G=0.0000
Asian	Sub	156	T=1.000	C=0.000, G=0.000
East Asian	Sub	130	T=1.000	C=0.000, G=0.000

The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure.

RATIONALE​

To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations.

RESULTS​

We identified 369 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 360 loci for which replication data were available, 241 loci influencing surface area and 66 influencing thickness remained significant after replication, with 237 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 50 influencing thickness).
Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness.

 

[rottingkyre]

Portugal 95

 

[Fabio]

Portugal 95 View attachment 35924

 

[Incellectual_Anon]

Moreover, two suggestive variants associated with putamen and caudate volumes exceeded genome-wide significance after meta-analysis across the discovery and replication data sets (Table 1). Effect sizes were similar across cohorts (P > 0.1, Cochran’s Q test; Extended Data Fig. 4b). Effect sizes remained consistent after excluding patients diagnosed with anxiety, Alzheimer’s disease, attention-deficit/hyperactivity disorder, bipolar disorder, epilepsy, major depressive disorder or schizophrenia (21% of the discovery participants). Correlation in effect size with and without patients was very high (r > 0.99) for loci with P < 1 × 10−5, indicating that these effects were unlikely to be driven by disease (Extended Data Fig. 5a). The participants’ age range covered most of the lifespan (9–97 years), but only one of the eight significant loci showed an effect related to the mean age of each cohort (P = 0.002; rs6087771 affecting putamen volume; Extended Data Fig. 5b), suggesting that nearly all effects are stable across the lifespan. In addition, none of these loci showed evidence of sex effects (Extended Data Fig. 5c).

rs1318862:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	22178	C=0.46736	A=0.00000, T=0.53264
European	Sub	19014	C=0.45051	A=0.00000, T=0.54949
African	Sub	1296	C=0.6096	A=0.0000, T=0.3904
African Others	Sub	66	C=0.65	A=0.00, T=0.35
African American	Sub	1230	C=0.6073	A=0.0000, T=0.3927
Asian	Sub	54	C=0.76	A=0.00, T=0.24
East Asian	Sub	46	C=0.80	A=0.00, T=0.20

Population	Group	Sample Size	Ref Allele	Alt Allele

rs61921502:

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	19550	T=0.87535	G=0.12465
European	Sub	14364	T=0.84788	G=0.15212
African	Sub	3380	T=0.9680	G=0.0320
African Others	Sub	114	T=1.000	G=0.000
African American	Sub	3266	T=0.9669	G=0.0331
Asian	Sub	146	T=0.993	G=0.007
East Asian	Sub	120	T=1.000	G=0.000

rs6087771:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	17654
European	Sub	12466	T=0.82031	C=0.17969, G=0.00000
East Asian	Sub	102	T=1.000	C=0.000, G=0.000

 

[NeverEndingWinter]

View attachment 35926

View attachment 35928



rs1318862:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	22178	C=0.46736	A=0.00000, T=0.53264
European	Sub	19014	C=0.45051	A=0.00000, T=0.54949
African	Sub	1296	C=0.6096	A=0.0000, T=0.3904
African Others	Sub	66	C=0.65	A=0.00, T=0.35
African American	Sub	1230	C=0.6073	A=0.0000, T=0.3927
Asian	Sub	54	C=0.76	A=0.00, T=0.24
East Asian	Sub	46	C=0.80	A=0.00, T=0.20

Population	Group	Sample Size	Ref Allele	Alt Allele

rs61921502:

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	19550	T=0.87535	G=0.12465
European	Sub	14364	T=0.84788	G=0.15212
African	Sub	3380	T=0.9680	G=0.0320
African Others	Sub	114	T=1.000	G=0.000
African American	Sub	3266	T=0.9669	G=0.0331
Asian	Sub	146	T=0.993	G=0.007
East Asian	Sub	120	T=1.000	G=0.000

rs6087771:

Population	Group	Sample Size	Ref Allele	Alt Allele

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	17654
European	Sub	12466	T=0.82031	C=0.17969, G=0.00000
East Asian	Sub	102	T=1.000	C=0.000, G=0.000

You gonna give us a quick rundown of what all that means?

 

[Fabio]

You gonna give us a quick rundown of what all that means?

 

[Incellectual_Anon]

You gonna give us a quick rundown of what all that means?

Potentially. I haven't sorted all of my data yet.

 

[NeverEndingWinter]

Potentially. I haven't sorted all of my data yet.

Does it mean white people are prone to mental illnesses? Is that what that data suggests?

 

[Asylum Patient]

Somalis only 68?
Da fuck man? Getting angry about that.