Discussion Highest values

[Lain]

What do you take as your highest values? Do you have a specific philosophy on life? My highest and ultimate value and aims is hedonism. There's some nuance to that, after all, if one becomes a heroin addict, they are definitely living the hedonistic lifestyle but it's also a significant amount of pain. I could rephrase it and say my life goal is minimizing suffering for as long as I live in my own life with pleasure as a side goal.

Minmaxxing neurotransmitters with a good diet, sleep and 30-60 mins of exercise, not stressing about things and taking mild dopamine agonists such as modafinil and kratom and caffeine puts me at a close to ideal state. Occasional NMDA antagonists to maximize serotonin but not in a harmful way. I've been drinking alchy the last 2ish days and I can say this isn't the hedonistic path, it lowers baseline stats and damages the body too much.

Maybe that's a selfish philosophy or way to think of life but I believe nearly everyone has hedonism as their main drive in life. They work so they can go home and enjoy what they've earned. They study to get social approval. Sometimes I think it's a shame I can't die for an irrational belief in a God, for my country, for my tribe, but it never clicks the same living surrounded by 500 different ethnicities that share whatever culture "American" means at this point.

Do you have higher values you'd ascribe past hedonism?

 

[rekamaður]

Self destruction (through passion, as well as passion itself)
Glory/subjective definition of greatness
Adventure

This is what I’ve always wanted most out of life, although I haven’t fully figured out how to accomplish them

The dream has always been to find something I’m so passionate about I’m willing to destroy myself over it. Achieve greatness in the process and overcome impossible obstacles (adventure)

 

[ChampagneHurricane]

Loyalty, I'm loyal to a fault.
Inquisitive, I enjoy learning and searching for the answers of questions.
Humor, at the end of the day, you gotta have fun right? Yes.

 

[akame]

I think the highest value of mine is patience, I have been put through many trials and will have many more to come, however, I know it's imperative that I keep my cool and continue moving forward even if things may appear overwhelming or even outright hopeless in some cases. If I give up than what am I even living for? So that is why I will have the patience to continue moving forwards no matter how many trials God challenges me with.

My second most important values are loyalty and passion which are important driving factors for me, I love dedicating myself to what I enjoy which can be a variety of things.

My negative traits would probably be my Wrath, Greed and obsession which funnily enough are the same side of the coin as my positive attributes.

 

[Deleted member 1545]

I have to take dopamine antagonists now such as paliperidone which make me lose dopamine.
But if I didn't check in the ward, the feds would have interrogated me.

 

[クーロ]

Self destruction (through passion, as well as passion itself)
Glory/subjective definition of greatness
Adventure

This is what I’ve always wanted most out of life, although I haven’t fully figured out how to accomplish them

The dream has always been to find something I’m so passionate about I’m willing to destroy myself over it. Achieve greatness in the process and overcome impossible obstacles (adventure)

A combination of this and Daoist ideas of "going with the flow" my aim in life is to live with as little stress as possible but also have extreme passion for whatever I work on. I guess my highest virtue is adaptability. Mentioned it a million times but my role model is Spike Spiegel. I want to be as calm, capable, and carefree as him

 

[Looksmax Refugee]

You <3

 

[tacticalskeleton]

Mindful Consumerism.

 

[CelticKHV]

I value my clean criminal record as it means I can look down on normies and sit on my high horse regardless of what they say about me.

 

[The Doctor]

How do NMDA antagonists increase serotonin?

 

[Saito]

Patience and willingness to understand.

 

[Lain]

How do NMDA antagonists increase serotonin?

Here's the mechanisms, although, I was drunk last night and kind of out of it, I would say that serotonin isn't this amazing thing that'll cure your depression or something like that. I've taken SSRIs and other serotonin agonists and what it does is sedate you in a different sense, at least from my experience. NMDA antagonists on the other hand mog and for different reasons. You already know though, having tried memantine. I'd say memantine is the most functional NMDA antagonist by far, you can take a low dose and chill all day. DXM is the worst. Ketamine is amazing but not functional whatsoever as you'll want to redose often.

It seems like modulation of glutamate is ideal for depression, with dopamine to give you a little extra push to be motivated to do things.

 

[The Doctor]

Here's the mechanisms, although, I was drunk last night and kind of out of it, I would say that serotonin isn't this amazing thing that'll cure your depression or something like that. I've taken SSRIs and other serotonin agonists and what it does is sedate you in a different sense, at least from my experience. NMDA antagonists on the other hand mog and for different reasons. You already know though, having tried memantine. I'd say memantine is the most functional NMDA antagonist by far, you can take a low dose and chill all day. DXM is the worst. Ketamine is amazing but not functional whatsoever as you'll want to redose often.
View attachment 169054
It seems like modulation of glutamate is ideal for depression, with dopamine to give you a little extra push to be motivated to do things.

Im interested if the overall effect is serotonergic (or if it's dose dependent). For example agonising 5 HT1a , 1b or 1d can lead to a net reduction in serotonin since these function as presynaptic autoreceptors which if agonised lead to net reduction in serotonin signalling in the brain. For example Memantine acts as an antagonist at 5 HT3, the net effect also seems to be anti-serotonergic

Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome - PubMed

Since memantine is clinically well tolerated, this drug is a particularly promising therapeutic drug for 5-HT syndrome treatment.

pubmed.ncbi.nlm.nih.gov

I like mematnine but cant sleep at night if I dose even more than 2 mg kek

 

[Lain]

Im interested if the overall effect is serotonergic (or if it's dose dependent). For example agonising 5 HT1a , 1b or 1d can lead to a net reduction in serotonin since these function as presynaptic autoreceptors which if agonised lead to net reduction in serotonin signalling in the brain. For example Memantine acts as an antagonist at 5 HT3, the net effect also seems to be anti-serotonergic

Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome - PubMed

Since memantine is clinically well tolerated, this drug is a particularly promising therapeutic drug for 5-HT syndrome treatment.

pubmed.ncbi.nlm.nih.gov

I like mematnine but cant sleep at night if I dose even more than 2 mg kek

I'd imagine that memantine has an overall serotonergic effect, because it doesn't directly agonize 5-HT1A receptors but it does work as a direct antagonist to 5-HT3 receptors. But I wouldn't attribute any of the positives from serotonin, I think serotonin primarily sedates people and lowers the capacity for thinking too much on emotional subjects, rather than increase positive feelings. You know, stimulants that increase dopamine+norepinephrine end up making you highly motivated and focused, memantine increasing that + but unlike stimulants that fuck with GABA, memantine can modulate GABA too. So you aren't as tweaked out. If you can't sleep at night I'd attribute that to the dopamine+norepinephrine effects though.

Drugs are very fascinating, something I think about a lot is how AI or just simple progression of science in the future will change how drugs are created and how they impact us. Imagine a drug that works as ideal as possible for whatever we want it to do, with no side effects, or so minimal it's not worth mentioning. Imagine something like amphetamines but it's 10x better and without a comedown or WDs. How that'd be made, I don't know. Do you think you'll ever try ketamine? If you're trying to be functional, maybe you shouldn't, but it is a pretty kino drug can't wait to get some K, I might be getting some today, been waiting for a week now

 

[The Doctor]

I'd imagine that memantine has an overall serotonergic effect, because it doesn't directly agonize 5-HT1A receptors but it does work as a direct antagonist to 5-HT3 receptors. But I wouldn't attribute any of the positives from serotonin, I think serotonin primarily sedates people and lowers the capacity for thinking too much on emotional subjects, rather than increase positive feelings. You know, stimulants that increase dopamine+norepinephrine end up making you highly motivated and focused, memantine increasing that + but unlike stimulants that fuck with GABA, memantine can modulate GABA too. So you aren't as tweaked out. If you can't sleep at night I'd attribute that to the dopamine+norepinephrine effects though.

Drugs are very fascinating, something I think about a lot is how AI or just simple progression of science in the future will change how drugs are created and how they impact us. Imagine a drug that works as ideal as possible for whatever we want it to do, with no side effects, or so minimal it's not worth mentioning. Imagine something like amphetamines but it's 10x better and without a comedown or WDs. How that'd be made, I don't know. Do you think you'll ever try ketamine? If you're trying to be functional, maybe you shouldn't, but it is a pretty kino drug can't wait to get some K, I might be getting some today, been waiting for a week now

yea ketamine seems very fascinating. Its also helped for anhedonia i think

 

[Deleted member 2463]

I would say irrationally or transgression, though it's hard to accept, Our values and virtues are transient in the span of history, so embracing the process is way better.

 

[404Errorcel]

Not sure if its my highest value but fighting for what you believe in and what you like. People will throw their beliefs out the window for any case and people will allow things they like to be made fun of by other people as an attempt to fit in. For example liberals will make fun conservatives for the same thing they believe in as a petty gotcha moment (vice versa). I don't like religion (and i have made fun of muslims and christians) but anyone that actually believes in it and will defend it has my respect then people who just sit there and take the whipping. Someone may like monster high and then allow themselves to be made of for it to fit in. Hell, you see it with nerds they make fun of other nerds just because there different. People should fight for what they like and defend it. I guess in layman's terms is hypocrisy and not defending what you like, i dislike it (and something i'm still trying to fix with myself). How can you respect yourself if you cant respect the things you like.

 

[lament]

Listening to my brain when it tells me to jerk off

 

[Pale God]

For me it‘s only doing what I want. Living like a king so to speak.

Coffee probably hurts you more than it benefits you. Wage cucks who didn’t go to bed early and have alarms drink that stuff.

 

[Eren]

I guess you could say utilitarianism with the end goal of serving myself, but I think that describes most people. Lately, I've been viewing values more as constructs.

 

[Kitten]

Hedonizsm iz gud! Iz nice ta feel happy. *Puurrs* But... peeple are... toys too, right? Hehehe!